作為世界領先的醫學期刊之一，《新英格蘭醫學雜志》在醫學的科學、藝術和實踐以及醫學在當今社會的地位等主要方面發表原創研究和解釋性文章。每周，該雜志都會發表以前未發表的主要研究成果、臨床發現、最新進展和觀點。

One of the world's leading medical journals, the NEJM publishes original research and interpretive articles in major aspects of medicine: its science, its art and practice, and its position in today's society. Each week, The Journal presents major, previously unpublished research results, clinical findings, updates and opinions.