該雜志發(fā)表了關(guān)于識(shí)別與疾病過(guò)程相關(guān)的標(biāo)記物的原始研究結(jié)果(以及編輯征求的評(píng)論)，無(wú)論這些標(biāo)記物是否是病變的組成部分。疾病標(biāo)記物可能是誘發(fā)疾病的遺傳宿主因子，也可能是細(xì)胞表面標(biāo)記物、酶或其他成分的發(fā)生，以改變的形式、異常的濃度或異常的組織分布。本雜志旨在為出版物提供一個(gè)論壇，討論這一發(fā)展中領(lǐng)域中關(guān)于一般主題的任何方面的原始觀察，包括:識(shí)別新的遺傳或非遺傳標(biāo)記(如細(xì)胞表面抗原、血清蛋白、細(xì)胞內(nèi)外酶、細(xì)胞遺傳學(xué)標(biāo)記和dna序列);新標(biāo)記物和現(xiàn)有標(biāo)記物的人口研究，旨在闡明其正態(tài)分布和疾病狀態(tài)的信息;擴(kuò)大現(xiàn)有標(biāo)記的知識(shí);疾病標(biāo)志物的家庭研究;識(shí)別和/或分離重要標(biāo)記分子的新技術(shù);利用單克隆抗體定義與疾病標(biāo)志物相關(guān)的分子結(jié)構(gòu);利用重組DNA技術(shù)、基因克隆和DNA限制性內(nèi)切酶片段多態(tài)性鑒定疾病相關(guān)的DNA異常;識(shí)別惡性轉(zhuǎn)化腫瘤細(xì)胞的標(biāo)記物。

The journal publishes original research findings (and reviews solicited by the Editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may be a genetic host factor predisposing to the disease or the occurrence of cell-surface markers, enzymes or other components, either in altered forms, abnormal concentrations or with abnormal tissue distribution. This journal is designed to provide a forum for publications dealing with original observations in this developing field on any aspect of the general topic including: Identification of new genetic or non-genetic markers (e.g., cell-surface antigens, serum proteins, intra- and extra-cellular enzymes, cytogenic markers and DNA-sequences); Population studies of new and existing markers, designed to elucidate information on their normal distribution as well as that in disease states; Amplification of knowledge about existing markers; Family studies of markers in disease; New techniques for identification and/or isolation of important marker molecules; Use of monoclonal antibodies for the definition of molecular structures associated with disease markers; Identification of disease-associated abnormalities in DNA using recombinant DNA techniques, gene-cloning and DNA restriction enzyme fragment polymorphisms; Identification of markers identifying malignantly transformed neoplastic cells