《毒理學(xué)機(jī)制與方法》是一份同行評(píng)審的期刊，每季出版一期，其目標(biāo)是雙重的。首先，該雜志包含了關(guān)于外來化學(xué)物質(zhì)引起毒性組織損傷機(jī)制的原始研究。感興趣的化學(xué)物質(zhì)包括工業(yè)化合物、環(huán)境污染物、危險(xiǎn)廢物、藥物、殺蟲劑和化學(xué)戰(zhàn)劑。該雜志的范圍從分子和細(xì)胞的作用機(jī)制，到考慮建立監(jiān)管政策的機(jī)制證據(jù)。其次，該雜志涉及開發(fā)、驗(yàn)證和應(yīng)用新的和現(xiàn)有的實(shí)驗(yàn)室方法、技術(shù)和設(shè)備。討論了多種研究方法，包括:用標(biāo)準(zhǔn)種和替代種進(jìn)行體內(nèi)研究;體外研究和替代方法;分子、生化和細(xì)胞技術(shù);藥物動(dòng)力學(xué)和藥效學(xué);數(shù)學(xué)建模和計(jì)算機(jī)程序;法醫(yī)分析;風(fēng)險(xiǎn)評(píng)估;數(shù)據(jù)收集和分析。毒理學(xué)機(jī)制和方法為來自工業(yè)、政府和學(xué)術(shù)界的毒理學(xué)家、藥理學(xué)家和生物化學(xué)家等眾多專業(yè)人士提供了關(guān)于有毒物質(zhì)測(cè)定、評(píng)價(jià)和檢測(cè)及其影響的最關(guān)鍵問題的全面報(bào)道。

Published quarterly, Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: in vivo studies with standard and alternative species; in vitro studies and alternative methodologies; molecular, biochemical, and cellular techniques; pharmacokinetics and pharmacodynamics; mathematical modeling and computer programs; forensic analyses; risk assessment; data collection and analysis. Toxicology Mechanisms and Methods provides comprehensive coverage of the most critical issues in the determination, evaluation and testing of toxic substances and their effects for a wide variety of professionals, including toxicologists, pharmacologists, and biochemists from industry, government and academia.